[Effect of buspirone and diazepam on cGMP level in the rat cerebellum]. / Vliianie buspirona i diazepama na soderzhanie tsGMF v mozzhechke krysy.
Biull Eksp Biol Med
; 102(9): 292-4, 1986 Sep.
Article
em Ru
| MEDLINE
| ID: mdl-3019447
ABSTRACT
Diazepam at a dose of 5 and 10 mg/kg significantly decreases (by 50 and 60%, respectively) cGMP content 30 min following intraperitoneal injection to rats. Buspirone, at a dose of 2.5-25 mg/kg produced a nonsignificant (up to 18%) and at a dose of 50 mg/kg a statistically significant (p less than 0.05) 30% decrease in cerebellum cGMP content. Taking into account the identical anxiolytic effects of diazepam and buspirone, it is suggested that pharmacological effects of buspirone are not linked to the activation of GABA-ergic system.
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Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Cerebelo
/
GMP Cíclico
/
Diazepam
Limite:
Animals
Idioma:
Ru
Revista:
Biull Eksp Biol Med
Ano de publicação:
1986
Tipo de documento:
Article