Long-term plasticity of hippocampal interneurons during in vivo memory processes.
Curr Opin Neurobiol
; 54: 20-27, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30195105
ABSTRACT
Formation of a cell assembly, a group of cortical neurons that function co-operatively to sustain an active memory trace, arises from changes in the connections between neurons. Establishment of memory traces is thought to rely on long-term plasticity in excitatory glutamatergic synapses interconnecting principal cells. In addition, recent studies in the hippocampus in vivo indicate that reconfiguration of GABAergic inhibitory interneuron activity also occurs during long-term memory encoding. Recent experiments in anesthetized, as well as in freely moving animals, demonstrate that learning-related hippocampal activities are associated with persistent changes in GABAergic interneuron firing rates and alterations in protein expression levels regulating GABA release.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Potenciação de Longa Duração
/
Hipocampo
/
Interneurônios
/
Memória
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Neurobiol
Assunto da revista:
BIOLOGIA
/
NEUROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article