Synthesis of CF<sub>3</sub>CH<sub>2</sub>-Containing Indolines by Transition-Metal-Free Aryltrifluoromethylation of Unactivated Alkenes.

Liang, Deqiang; Dong, Qishan; Xu, Penghui; Dong, Ying; Li, Weili; Ma, Yinhai

Synthesis of CF₃CH₂-Containing Indolines by Transition-Metal-Free Aryltrifluoromethylation of Unactivated Alkenes.

Liang, Deqiang; Dong, Qishan; Xu, Penghui; Dong, Ying; Li, Weili; Ma, Yinhai.

Afiliação

Liang D; Department of Chemistry , Kunming University , Kunming 650214 , China.
Dong Q; Yunnan Engineering Technology Research Center for Plastic Films , Kunming 650214 , China.
Xu P; Department of Chemistry , Kunming University , Kunming 650214 , China.
Dong Y; Department of Chemistry , Kunming University , Kunming 650214 , China.
Li W; College of Chemistry, Chemical Engineering and Materials Science , Shandong Normal University , Jinan 250014 , China.
Ma Y; Yunnan Engineering Technology Research Center for Plastic Films , Kunming 650214 , China.

J Org Chem ; 83(19): 11978-11986, 2018 10 05.

Article em En | MEDLINE | ID: mdl-30198264

ABSTRACT

ABSTRACT

With an unactivated double bond as the radical acceptor, allyl amines underwent a metal-free trifluoromethylation/cyclization cascade with CF3SO2Na (Langlois' reagent), affording CF3CH2-containing indolines and tetrahydroisoquinolines, whose practical syntheses are significant challenges. This protocol features mild conditions, low cost, and a broad substrate scope.

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: J Org Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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