TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.

Tsutsui, Masato; Hirase, Ryo; Miyamura, Sakie; Nagayasu, Kazuki; Nakagawa, Takayuki; Mori, Yasuo; Shirakawa, Hisashi; Kaneko, Shuji

Tsutsui, Masato; Hirase, Ryo; Miyamura, Sakie; Nagayasu, Kazuki; Nakagawa, Takayuki; Mori, Yasuo; Shirakawa, Hisashi; Kaneko, Shuji.

Afiliação

Tsutsui M; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Hirase R; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Miyamura S; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Nagayasu K; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Nakagawa T; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan, and.
Mori Y; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto 615-8510, Japan.
Shirakawa H; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan, shirakaw@pharm.kyoto-u.ac.jp.
Kaneko S; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

J Neurosci ; 38(39): 8484-8495, 2018 09 26.

Article em En | MEDLINE | ID: mdl-30201769

Assuntos

Quimiocina CXCL2/imunologia; Encefalomielite Autoimune Experimental/imunologia; Esclerose Múltipla/imunologia; Canais de Cátion TRPM/imunologia; Animais; Proteínas de Ligação ao Cálcio/imunologia; Proteínas de Ligação ao Cálcio/metabolismo; Quimiocina CXCL2/metabolismo; Encefalomielite Autoimune Experimental/metabolismo; Feminino; Macrófagos/imunologia; Macrófagos/metabolismo; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteínas dos Microfilamentos/imunologia; Proteínas dos Microfilamentos/metabolismo; Monócitos/imunologia; Monócitos/metabolismo; Esclerose Múltipla/metabolismo; Infiltração de Neutrófilos; Canais de Cátion TRPM/genética; Canais de Cátion TRPM/metabolismo

Palavras-chave

TRP channel; TRPM2; cxcl2; macrophage; multiple sclerosis; neutrophil

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Canais de Cátion TRPM / Quimiocina CXCL2 / Esclerose Múltipla Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão

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