<i>In silico</i> screening of deleterious single nucleotide polymorphisms (SNPs) and molecular dynamics simulation of disease associated mutations in gene responsible for oculocutaneous albinism type 6 (OCA 6) disorder.

Kumar, Rutash; Bansal, Ankush; Shukla, Rohit; Raj Singh, Tiratha; Wasudeo Ramteke, Pramod; Singh, Satendra; Gautam, Budhayash

In silico screening of deleterious single nucleotide polymorphisms (SNPs) and molecular dynamics simulation of disease associated mutations in gene responsible for oculocutaneous albinism type 6 (OCA 6) disorder.

Kumar, Rutash; Bansal, Ankush; Shukla, Rohit; Raj Singh, Tiratha; Wasudeo Ramteke, Pramod; Singh, Satendra; Gautam, Budhayash.

Afiliação

Kumar R; a Department of Computational Biology & Bioinformatics , Jacob Institute of Biotechnology & Bio-Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS) , Allahabad , India.
Bansal A; b Department of Biotechnology and Bioinformatics , Jaypee University of Information Technology , Solan , India.
Shukla R; b Department of Biotechnology and Bioinformatics , Jaypee University of Information Technology , Solan , India.
Raj Singh T; b Department of Biotechnology and Bioinformatics , Jaypee University of Information Technology , Solan , India.
Wasudeo Ramteke P; a Department of Computational Biology & Bioinformatics , Jacob Institute of Biotechnology & Bio-Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS) , Allahabad , India.
Singh S; a Department of Computational Biology & Bioinformatics , Jacob Institute of Biotechnology & Bio-Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS) , Allahabad , India.
Gautam B; a Department of Computational Biology & Bioinformatics , Jacob Institute of Biotechnology & Bio-Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS) , Allahabad , India.

J Biomol Struct Dyn ; 37(13): 3513-3523, 2019 08.

Article em En | MEDLINE | ID: mdl-30204049

Assuntos

Albinismo Oculocutâneo/genética; Antiporters/química; Antiporters/metabolismo; Simulação de Dinâmica Molecular; Proteínas Mutantes/química; Proteínas Mutantes/metabolismo; Polimorfismo de Nucleotídeo Único; Antiporters/genética; Sítios de Ligação; Biologia Computacional; Humanos; Modelos Moleculares; Proteínas Mutantes/genética; Mutação; Ligação Proteica; Conformação Proteica

Palavras-chave

modelling; OCA; molecular dynamics simulation; mutations; nsSNPs

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Albinismo Oculocutâneo / Antiporters / Polimorfismo de Nucleotídeo Único / Proteínas Mutantes / Simulação de Dinâmica Molecular Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Humans Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Índia

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