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Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity.
De Vita, Elena; Schüler, Peter; Lovell, Scott; Lohbeck, Jasmin; Kullmann, Sven; Rabinovich, Eitan; Sananes, Amiram; Heßling, Bernd; Hamon, Veronique; Papo, Niv; Hess, Jochen; Tate, Edward W; Gunkel, Nikolas; Miller, Aubry K.
Afiliação
  • De Vita E; Cancer Drug Development Group , German Cancer Research Center (DKFZ) , Heidelberg 69120 , Germany.
  • Schüler P; Biosciences Faculty , University of Heidelberg , Heidelberg 69120 , Germany.
  • Lovell S; Cancer Drug Development Group , German Cancer Research Center (DKFZ) , Heidelberg 69120 , Germany.
  • Lohbeck J; Department of Chemistry , Imperial College London , Exhibition Road , London SW7 2AZ , U.K.
  • Kullmann S; Cancer Drug Development Group , German Cancer Research Center (DKFZ) , Heidelberg 69120 , Germany.
  • Rabinovich E; Cancer Drug Development Group , German Cancer Research Center (DKFZ) , Heidelberg 69120 , Germany.
  • Sananes A; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev , Ben-Gurion University of the Negev , Beer-Sheva 84105 , Israel.
  • Heßling B; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev , Ben-Gurion University of the Negev , Beer-Sheva 84105 , Israel.
  • Hamon V; Center for Molecular Biology , University of Heidelberg , Heidelberg 69120 , Germany.
  • Papo N; European Screening Centre, Biocity Scotland , University of Dundee , Newhouse ML1 5UH , U.K.
  • Hess J; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev , Ben-Gurion University of the Negev , Beer-Sheva 84105 , Israel.
  • Tate EW; Department of Otorhinolaryngology, Head and Neck Surgery , Heidelberg University Hospital , Heidelberg 69120 , Germany.
  • Gunkel N; Research Group Molecular Mechanisms of Head and Neck Tumors , German Cancer Research Center (DKFZ) , Heidelberg 69120 , Germany.
  • Miller AK; Department of Chemistry , Imperial College London , Exhibition Road , London SW7 2AZ , U.K.
J Med Chem ; 61(19): 8859-8874, 2018 10 11.
Article em En | MEDLINE | ID: mdl-30212625
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calicreínas / Depsipeptídeos / Proliferação de Células / Inibidores Enzimáticos / Neoplasias Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calicreínas / Depsipeptídeos / Proliferação de Células / Inibidores Enzimáticos / Neoplasias Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha