Defining hrHPV genotypes in cervical intraepithelial neoplasia by laser capture microdissection supports reflex triage of self-samples using HPV16/18 and FAM19A4/miR124-2 methylation.

Leeman, Annemiek; Ebisch, Renée M F; Kasius, Annemieke; Bosgraaf, Remko P; Jenkins, David; van de Sandt, Miekel M; de Strooper, Lise M A; Heideman, Daniëlle A M; Snijders, Peter J F; Massuger, Leon F A G; Bekkers, Ruud L M; Meijer, Chris J L M; van Kemenade, Folkert J; Quint, Wim G V; Melchers, Willem J G

Leeman, Annemiek; Ebisch, Renée M F; Kasius, Annemieke; Bosgraaf, Remko P; Jenkins, David; van de Sandt, Miekel M; de Strooper, Lise M A; Heideman, Daniëlle A M; Snijders, Peter J F; Massuger, Leon F A G; Bekkers, Ruud L M; Meijer, Chris J L M; van Kemenade, Folkert J; Quint, Wim G V; Melchers, Willem J G.

Afiliação

Leeman A; DDL Diagnostic Laboratory, Rijswijk, the Netherlands.
Ebisch RMF; Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, the Netherlands.
Kasius A; DDL Diagnostic Laboratory, Rijswijk, the Netherlands.
Bosgraaf RP; Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, the Netherlands.
Jenkins D; DDL Diagnostic Laboratory, Rijswijk, the Netherlands.
van de Sandt MM; DDL Diagnostic Laboratory, Rijswijk, the Netherlands.
de Strooper LMA; Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Heideman DAM; Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Snijders PJF; Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Massuger LFAG; Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, the Netherlands.
Bekkers RLM; Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, the Netherlands; Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, the Netherlands.
Meijer CJLM; Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
van Kemenade FJ; Erasmus Medical Center, Department of Pathology, Rotterdam, the Netherlands.
Quint WGV; DDL Diagnostic Laboratory, Rijswijk, the Netherlands. Electronic address: wim.quint@ddl.nl.
Melchers WJG; Department of Medical Microbiology, Radboud university medical center, Nijmegen, the Netherlands.

Gynecol Oncol ; 151(2): 311-318, 2018 11.

Article em En | MEDLINE | ID: mdl-30219239

Assuntos

Citocinas/metabolismo; Papillomavirus Humano 16/genética; Papillomavirus Humano 18/genética; MicroRNAs/metabolismo; Infecções por Papillomavirus/virologia; Displasia do Colo do Útero/virologia; Neoplasias do Colo do Útero/virologia; Adulto; Biópsia; Citocinas/genética; Metilação de DNA; Feminino; Genótipo; Humanos; Microdissecção e Captura a Laser; MicroRNAs/genética; Pessoa de Meia-Idade; Infecções por Papillomavirus/genética; Infecções por Papillomavirus/metabolismo; Infecções por Papillomavirus/patologia; Neoplasias do Colo do Útero/genética; Neoplasias do Colo do Útero/metabolismo; Neoplasias do Colo do Útero/patologia; Displasia do Colo do Útero/genética; Displasia do Colo do Útero/metabolismo; Displasia do Colo do Útero/patologia

Palavras-chave

Cervical cancer; Cervical intraepithelial neoplasia; Human papillomavirus; Methylation; Self-sampling; Triage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Displasia do Colo do Útero / Neoplasias do Colo do Útero / Citocinas / Infecções por Papillomavirus / MicroRNAs / Papillomavirus Humano 16 / Papillomavirus Humano 18 Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Gynecol Oncol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda

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