Recent Breakthroughs and Ongoing Limitations in Cryptosporidium Research.
F1000Res
; 72018.
Article
em En
| MEDLINE
| ID: mdl-30228873
ABSTRACT
The intestinal apicomplexan parasite Cryptosporidium is a major cause of diarrheal disease in humans worldwide. However, treatment options are severely limited. The search for novel interventions is imperative, yet there are several challenges to drug development, including intractability of the parasite and limited technical tools to study it. This review addresses recent, exciting breakthroughs in this field, including novel cell culture models, strategies for genetic manipulation, transcriptomics, and promising new drug candidates. These advances will stimulate the ongoing quest to understand Cryptosporidium and the pathogenesis of cryptosporidiosis and to develop new approaches to combat this disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Criptosporidiose
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Cryptosporidium
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Descoberta de Drogas
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Antiprotozoários
Limite:
Animals
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Humans
Idioma:
En
Revista:
F1000Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos