Synthetic repetitive extragenic palindromic (REP) sequence as an efficient mRNA stabilizer for protein production and metabolic engineering in prokaryotic cells.

Deng, Chen; Lv, Xueqin; Li, Jianghua; Liu, Yanfeng; Du, Guocheng; Amaro, Rodrigo Ledesma; Liu, Long

Deng, Chen; Lv, Xueqin; Li, Jianghua; Liu, Yanfeng; Du, Guocheng; Amaro, Rodrigo Ledesma; Liu, Long.

Afiliação

Deng C; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.
Lv X; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.
Li J; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.
Liu Y; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.
Du G; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.
Amaro RL; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.
Liu L; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.

Biotechnol Bioeng ; 116(1): 5-18, 2019 01.

Article em En | MEDLINE | ID: mdl-30229865

Assuntos

Corynebacterium glutamicum/metabolismo; Escherichia coli/metabolismo; Sequências Repetidas Invertidas; Engenharia Metabólica/métodos; Estabilidade de RNA; RNA Mensageiro/metabolismo; Proteínas Recombinantes/biossíntese; Acetilglucosamina/biossíntese; Corynebacterium glutamicum/genética; Escherichia coli/genética; Glucosiltransferases/biossíntese; Glucosiltransferases/genética; RNA Mensageiro/genética; Proteínas Recombinantes/genética

Palavras-chave

mRNA stability; metabolic engineering; protein engineering; repetitive extragenic palindromic sequence

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes / RNA Mensageiro / Estabilidade de RNA / Corynebacterium glutamicum / Escherichia coli / Sequências Repetidas Invertidas / Engenharia Metabólica Tipo de estudo: Clinical_trials Idioma: En Revista: Biotechnol Bioeng Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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