Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP.
Mol Cell Oncol
; 5(4): e1441630, 2018.
Article
em En
| MEDLINE
| ID: mdl-30250908
ABSTRACT
ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Israel