Evolved Mechanisms of Aerobic Performance and Hypoxia Resistance in High-Altitude Natives.
Annu Rev Physiol
; 81: 561-583, 2019 02 10.
Article
em En
| MEDLINE
| ID: mdl-30256727
ABSTRACT
Comparative physiology studies of high-altitude species provide an exceptional opportunity to understand naturally evolved mechanisms of hypoxia resistance. Aerobic capacity (VO2max) is a critical performance trait under positive selection in some high-altitude taxa, and several high-altitude natives have evolved to resist the depressive effects of hypoxia on VO2max. This is associated with enhanced flux capacity through the O2 transport cascade and attenuation of the maladaptive responses to chronic hypoxia that can impair O2 transport. Some highlanders exhibit elevated rates of carbohydrate oxidation during exercise, taking advantage of its high ATP yield per mole of O2. Certain highland native animals have also evolved more oxidative muscles and can sustain high rates of lipid oxidation to support thermogenesis. The underlying mechanisms include regulatory adjustments of metabolic pathways and to gene expression networks. Therefore, the evolution of hypoxia resistance in high-altitude natives involves integrated functional changes in the pathways for O2 and substrate delivery and utilization by mitochondria.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
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Pressão Atmosférica
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Termogênese
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Grupos Populacionais
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Evolução Biológica
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Hipóxia
Limite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Physiol
Ano de publicação:
2019
Tipo de documento:
Article