Your browser doesn't support javascript.
loading
Colorectal carcinogenesis: an archetype of gut microbiota-host interaction.
Alexander, James L; Scott, Alasdair J; Pouncey, Anna L; Marchesi, Julian; Kinross, James; Teare, Julian.
Afiliação
  • Alexander JL; Centre for Digestive and Gut Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Building, St Mary's Hospital, South Wharf Road, London W2 1NY, UK.
  • Scott AJ; Centre for Digestive and Gut Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Building, St Mary's Hospital, South Wharf Road, London W2 1NY, UK.
  • Pouncey AL; Centre for Digestive and Gut Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Building, St Mary's Hospital, South Wharf Road, London W2 1NY, UK.
  • Marchesi J; Centre for Digestive and Gut Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Building, St Mary's Hospital, South Wharf Road, London W2 1NY, UK.
  • Kinross J; Centre for Digestive and Gut Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Building, St Mary's Hospital, South Wharf Road, London W2 1NY, UK.
  • Teare J; Centre for Digestive and Gut Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Building, St Mary's Hospital, South Wharf Road, London W2 1NY, UK.
Ecancermedicalscience ; 12: 865, 2018.
Article em En | MEDLINE | ID: mdl-30263056
Sporadic colorectal cancer (CRC) remains a major cause of worldwide mortality. Epidemiological evidence of markedly increased risk in populations that migrate to Western countries, or adopt their lifestyle, suggests that CRC is a disease whose aetiology is defined primarily by interactions between the host and his environment. The gut microbiome sits directly at this interface and is now increasingly recognised as a modulator of colorectal carcinogenesis. Bacteria such as Fusobacterium nucleatum and Escherichia coli (E. Coli) are found in abundance in patients with CRC and have been shown in experimental studies to promote neoplasia. A whole armamentarium of bacteria-derived oncogenic mechanisms has been defined, including the subversion of apoptosis and the production of genotoxins and pro-inflammatory factors. But the microbiota may also be protective: for example, they are implicated in the metabolism of dietary fibre to produce butyrate, a short chain fatty acid, which is anti-inflammatory and anti-carcinogenic. Indeed, although our understanding of this immensely complex, highly individualised and multi-faceted relationship is expanding rapidly, many questions remain: Can we define friends and foes, and drivers and passengers? What are the critical functions of the microbiota in the context of colorectal neoplasia?
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Ecancermedicalscience Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Ecancermedicalscience Ano de publicação: 2018 Tipo de documento: Article