Reward-related brain structures are smaller in patients with schizophrenia and comorbid metabolic syndrome.
Acta Psychiatr Scand
; 138(6): 581-590, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30264457
ABSTRACT
OBJECTIVE:
Metabolic syndrome (MS) is highly prevalent in schizophrenia and often a consequence of unhealthy behaviour. Reward-related brain areas might be associated with MS, since they play a major role in regulating health behaviour. This study examined the relationship between MS and brain volumes related to the reward system in schizophrenia.METHOD:
We included patients with schizophrenia, with MS (MS+; n = 23), patients with schizophrenia, without MS (MS-; n = 48), and healthy controls (n = 54). Global brain volumes and volumes of (sub)cortical areas, part of the reward circuit, were compared between patients and controls. In case of a significant brain volume difference between patients and controls, the impact of MS in schizophrenia was examined.RESULTS:
Patients had smaller total brain (TB; P = 0.001), GM (P = 0.010), larger ventricles (P = 0.026), and smaller reward circuit volume (P < 0.001) than controls. MS+ had smaller TB (P = 0.017), GM (P = 0.008), larger ventricles (P = 0.015), and smaller reward circuit volume (P = 0.002) than MS-. MS+ had smaller orbitofrontal cortex (OFC; P = 0.002) and insula volumes (P = 0.005) and smaller OFC (P = 0.008) and insula cortical surface area (P = 0.025) compared to MS-.CONCLUSION:
In schizophrenia, structural brain volume reductions in areas of the reward circuitry appear to be related to comorbid MS.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Recompensa
/
Esquizofrenia
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Encéfalo
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Síndrome Metabólica
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Rede Nervosa
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Holanda