A [11 C] CO dispensing system for rapid screening of carbonylation reactions.
J Labelled Comp Radiopharm
; 61(14): 1110-1114, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30286517
ABSTRACT
[11 C] CO is a highly versatile synthon that allows for labeling at carbonyl positions of many molecules by means of transition metal-mediated carbonylation reactions. The intrinsic complexity of carbonylation reactions often requires tedious screening of reaction conditions for obtaining satisfying yields. Herein, a [11 C] CO dispending system for performing multiple reactions with a single batch of cyclotron-produced [11 C]CO2 is described. This semiautomated setup allows for more rapid and efficient screening of reactions and reaction conditions compared with the traditional "one beam for one reaction" strategy.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Radioquímica
/
Monóxido de Carbono
/
Radioisótopos de Carbono
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
J Labelled Comp Radiopharm
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos