Heterochromatin restricts the mobility of nuclear bodies.
Chromosoma
; 127(4): 529-537, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30291421
ABSTRACT
Nuclear bodies are relatively immobile organelles. Here, we investigated the mechanisms underlying their movement using experimentally induced interphase prenucleolar bodies (iPNBs). Most iPNBs demonstrated constrained diffusion, exhibiting infrequent fusions with other iPNBs and nucleoli. Fusion events were actin-independent and appeared to be the consequence of stochastic collisions between iPNBs. Most iPNBs were surrounded by condensed chromatin, while fusing iPNBs were usually found in a single heterochromatin-delimited compartment ("cage"). The experimentally induced over-condensation of chromatin significantly decreased the frequency of iPNB fusion. Thus, the data obtained indicate that the mobility of nuclear bodies is restricted by heterochromatin.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Heterocromatina
/
Estruturas do Núcleo Celular
Limite:
Humans
Idioma:
En
Revista:
Chromosoma
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Federação Russa