Decoding Transcriptome Dynamics of Genome-Encoded Polyadenylation and Autoregulation with Small-Molecule Modulators of Alternative Polyadenylation.

Araki, Shinsuke; Nakayama, Yusuke; Sano, Osamu; Nakao, Shoichi; Shimizu-Ogasawara, Mari; Toyoshiba, Hiroyoshi; Nakanishi, Atsushi; Aparicio, Samuel

Araki, Shinsuke; Nakayama, Yusuke; Sano, Osamu; Nakao, Shoichi; Shimizu-Ogasawara, Mari; Toyoshiba, Hiroyoshi; Nakanishi, Atsushi; Aparicio, Samuel.

Afiliação

Araki S; Research Department, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: shinsuke.araki@takeda.com.
Nakayama Y; Research Department, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Sano O; Research Department, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Nakao S; Research Department, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Shimizu-Ogasawara M; Research Department, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Toyoshiba H; Research Department, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Nakanishi A; Research Department, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Aparicio S; Molecular Oncology, BC Cancer Agency, 675 W 10th Avenue, Vancouver, BC V5Z 1L3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada. Electronic address: saparicio@bccrc.ca.

Cell Chem Biol ; 25(12): 1470-1484.e5, 2018 12 20.

Article em En | MEDLINE | ID: mdl-30293940

Assuntos

Poliadenilação/efeitos dos fármacos; Poliadenilação/genética; Bibliotecas de Moléculas Pequenas/farmacologia; Transcriptoma/efeitos dos fármacos; Linhagem Celular; Feminino; Homeostase/efeitos dos fármacos; Humanos; Bibliotecas de Moléculas Pequenas/química; Transcriptoma/genética

Palavras-chave

PABPN1; RNA binding protein; alternative polyadenylation; alternative polyadenylation modulator; autoregulation; reporter screening

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliadenilação / Bibliotecas de Moléculas Pequenas / Transcriptoma Limite: Female / Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2018 Tipo de documento: Article

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