Protection from ischemia-induced cerebral edema in the rat by U-50488H, a kappa opioid receptor agonist.
Brain Res
; 403(1): 52-7, 1987 Feb 10.
Article
em En
| MEDLINE
| ID: mdl-3030502
ABSTRACT
U-50488 is a specific kappa opioid agonist which produces in rats water diuresis resulting in an elevation of plasma osmolarity. Pretreatment with U-50488H (the methanesulfonate salt) in Fisher rats prior to 4 h of bilateral carotid occlusion prevented the development of edema in the forebrain, and the effect was greater than that from pentobarbital anesthesia. An additional injection of an antidiuretic hormone which prevented the plasma hyperosmolarity also significantly reduced the anticerebral edemic effects of U-50488H. The plasma osmotic effect, however, may not completely account for the ischemic protection produced by U-50488H.
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Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Edema Encefálico
/
Isquemia Encefálica
/
Receptores Opioides
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1987
Tipo de documento:
Article