SUMO protease SENP1 deSUMOylates and stabilizes c-Myc.

Sun, Xiao-Xin; Chen, Yingxiao; Su, Yulong; Wang, Xiaoyan; Chauhan, Krishna Mohan; Liang, Juan; Daniel, Colin J; Sears, Rosalie C; Dai, Mu-Shui

Sun, Xiao-Xin; Chen, Yingxiao; Su, Yulong; Wang, Xiaoyan; Chauhan, Krishna Mohan; Liang, Juan; Daniel, Colin J; Sears, Rosalie C; Dai, Mu-Shui.

Afiliação

Sun XX; Department of Molecular & Medical Genetics, School of Medicine, Oregon Health & Science University, Portland, OR 97239; sunx@ohsu.edu searsr@ohsu.edu daim@ohsu.edu.
Chen Y; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Su Y; Department of Molecular & Medical Genetics, School of Medicine, Oregon Health & Science University, Portland, OR 97239.
Wang X; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Chauhan KM; Department of Molecular & Medical Genetics, School of Medicine, Oregon Health & Science University, Portland, OR 97239.
Liang J; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Daniel CJ; Department of Molecular & Medical Genetics, School of Medicine, Oregon Health & Science University, Portland, OR 97239.
Sears RC; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239.
Dai MS; Department of Molecular & Medical Genetics, School of Medicine, Oregon Health & Science University, Portland, OR 97239.

Proc Natl Acad Sci U S A ; 115(43): 10983-10988, 2018 10 23.

Article em En | MEDLINE | ID: mdl-30305424

Assuntos

Cisteína Endopeptidases/metabolismo; Proteínas Proto-Oncogênicas c-myc/metabolismo; Proteína SUMO-1/metabolismo; Neoplasias da Mama/metabolismo; Pontos de Checagem do Ciclo Celular/fisiologia; Linhagem Celular; Linhagem Celular Tumoral; Proliferação de Células/fisiologia; Feminino; Células HCT116; Células HEK293; Células HeLa; Humanos; Células MCF-7; Complexo de Endopeptidases do Proteassoma/metabolismo; Processamento de Proteína Pós-Traducional/fisiologia; Sumoilação/fisiologia; Ubiquitinação/fisiologia

Palavras-chave

SENP1; SUMOylation; c-Myc; deSUMOylation; ubiquitination

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cisteína Endopeptidases / Proteínas Proto-Oncogênicas c-myc / Proteína SUMO-1 Limite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google