Tumorigenic PVT-1 gene locus is governed by miR-2909 RNomics.
Cell Biochem Funct
; 36(8): 408-412, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30318596
ABSTRACT
Genomic regulation and functional significance of PVT-1 gene locus, in the MYC-driven cancers, has remained enigmatic ever since its discovery. With the present study, an attempt is made to establish that cellular AATF genome encoded miR-2909 RNomics pathway involving crucial genes coding for KLF4, Deptor, mTORC1, STAT3, and p53 has the inherent capacity to ensure sustained co-amplification of PVT-1 gene locus together with c-Myc gene. Based upon these results, we propose that miR-2909 RNomics pathway may play a crucial role in the regulation of tumorigenic PVT-1 gene locus.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
/
RNA Longo não Codificante
Limite:
Humans
Idioma:
En
Revista:
Cell Biochem Funct
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Índia