Spermatogenesis dysfunction induced by PM<sub>2.5</sub> from automobile exhaust via the ROS-mediated MAPK signaling pathway.

Liu, Bin; Wu, Sheng-De; Shen, Lian-Ju; Zhao, Tian-Xin; Wei, Yi; Tang, Xiang-Liang; Long, Chun-Lan; Zhou, Yue; He, Da-Wei; Lin, Tao; Wei, Guang-Hui

Spermatogenesis dysfunction induced by PM_2.5 from automobile exhaust via the ROS-mediated MAPK signaling pathway.

Liu, Bin; Wu, Sheng-De; Shen, Lian-Ju; Zhao, Tian-Xin; Wei, Yi; Tang, Xiang-Liang; Long, Chun-Lan; Zhou, Yue; He, Da-Wei; Lin, Tao; Wei, Guang-Hui.

Afiliação

Liu B; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
Wu SD; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
Shen LJ; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
Zhao TX; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
Wei Y; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
Tang XL; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
Long CL; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
Zhou Y; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
He DW; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
Lin T; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International
Wei GH; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International

Ecotoxicol Environ Saf ; 167: 161-168, 2019 Jan 15.

Article em En | MEDLINE | ID: mdl-30326357

Assuntos

Proteínas Quinases Ativadas por Mitógeno/metabolismo; Estresse Oxidativo; Material Particulado/toxicidade; Espécies Reativas de Oxigênio/metabolismo; Espermatogênese/efeitos dos fármacos; Emissões de Veículos/toxicidade; Animais; Antioxidantes/farmacologia; Ácido Ascórbico/farmacologia; Barreira Hematotesticular/metabolismo; Caspase 3/metabolismo; Conexina 43/metabolismo; Fertilidade/efeitos dos fármacos; Masculino; Malondialdeído/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; Ocludina/metabolismo; Fosforilação/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Distribuição Aleatória; Ratos; Ratos Sprague-Dawley; Análise do Sêmen; Transdução de Sinais; Espermatozoides/efeitos dos fármacos; Superóxido Dismutase/metabolismo; Vitamina E/farmacologia; Proteína da Zônula de Oclusão-1/metabolismo; Proteína X Associada a bcl-2/metabolismo; beta Catenina/metabolismo

Palavras-chave

Bloodtestis barrier; MAPKs; PM(2.5); Reproductive toxicity; Vitamins

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espermatogênese / Emissões de Veículos / Espécies Reativas de Oxigênio / Estresse Oxidativo / Proteínas Quinases Ativadas por Mitógeno / Material Particulado Limite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Ano de publicação: 2019 Tipo de documento: Article

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