Protective role of down-regulated microRNA-31 on intestinal barrier dysfunction through inhibition of NF-&#954;B/HIF-1&#945; pathway by binding to HMOX1 in rats with sepsis.

Zhan, Cheng-Ye; Chen, Di; Luo, Jin-Long; Shi, Ying-Hua; Zhang, You-Ping

Protective role of down-regulated microRNA-31 on intestinal barrier dysfunction through inhibition of NF-κB/HIF-1α pathway by binding to HMOX1 in rats with sepsis.

Zhan, Cheng-Ye; Chen, Di; Luo, Jin-Long; Shi, Ying-Hua; Zhang, You-Ping.

Afiliação

Zhan CY; Intensive Care Unit, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, No. 1095, Jiefang Road, Qiaokou District, Wuhan, 430030, Hubei Province, People's Republic of China.
Chen D; Intensive Care Unit, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, No. 1095, Jiefang Road, Qiaokou District, Wuhan, 430030, Hubei Province, People's Republic of China. cdchendi2018@126.com.
Luo JL; Intensive Care Unit, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, No. 1095, Jiefang Road, Qiaokou District, Wuhan, 430030, Hubei Province, People's Republic of China.
Shi YH; Intensive Care Unit, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, No. 1095, Jiefang Road, Qiaokou District, Wuhan, 430030, Hubei Province, People's Republic of China.
Zhang YP; Intensive Care Unit, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, No. 1095, Jiefang Road, Qiaokou District, Wuhan, 430030, Hubei Province, People's Republic of China.

Mol Med ; 24(1): 55, 2018 10 19.

Article em En | MEDLINE | ID: mdl-30340459

Assuntos

Heme Oxigenase-1/fisiologia; Subunidade alfa do Fator 1 Induzível por Hipóxia/antagonistas & inibidores; Intestinos/fisiologia; MicroRNAs; NF-kappa B/antagonistas & inibidores; Sepse/genética; Animais; Células CACO-2; Regulação para Baixo; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/fisiologia; Masculino; NF-kappa B/fisiologia; Ratos Sprague-Dawley; Sepse/metabolismo; Transdução de Sinais

Palavras-chave

HMOX1; Intestinal barrier dysfunction; NF-κB/HIF-1α pathway; Sepsis; microRNA-31

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Sepse / MicroRNAs / Heme Oxigenase-1 / Subunidade alfa do Fator 1 Induzível por Hipóxia / Intestinos Limite: Animals / Humans / Male Idioma: En Revista: Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article

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