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Pharmacological inhibition of bacterial ß-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo.
Cheng, Kai-Wen; Tseng, Chih-Hua; Tzeng, Cherng-Chyi; Leu, Yu-Lin; Cheng, Ta-Chun; Wang, Jaw-Yuan; Chang, Jia-Ming; Lu, Yun-Chi; Cheng, Chiu-Min; Chen, I-Ju; Cheng, Yi-An; Chen, Yeh-Long; Cheng, Tian-Lu.
Afiliação
  • Cheng KW; Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Tseng CH; School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Pharmacy,
  • Tzeng CC; Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Leu YL; Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan.
  • Cheng TC; Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Wang JY; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Division of Gastroenterology and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
  • Chang JM; Department of Animal Pharmacology, Development Center for Biotechnology, New Taipei City 221, Taiwan; Preclinical Animal Pharmacology Testing Center, National Research Program, National Research Program, New Taipei City 221, Taiwan.
  • Lu YC; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Cheng CM; Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, Kaohsiung 807, Taiwan.
  • Chen IJ; Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Cheng YA; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Chen YL; Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: yeloch@kmu.edu.tw.
  • Cheng TL; Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Biomedical and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Tai
Pharmacol Res ; 139: 41-49, 2019 01.
Article em En | MEDLINE | ID: mdl-30391354
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Proteínas de Bactérias / Neoplasias do Colo / Diarreia / Irinotecano / Glucuronidase / Antineoplásicos Fitogênicos Limite: Animals / Humans / Male Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Taiwan
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Proteínas de Bactérias / Neoplasias do Colo / Diarreia / Irinotecano / Glucuronidase / Antineoplásicos Fitogênicos Limite: Animals / Humans / Male Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Taiwan