[Effect of sublingual dust mite drops on single or multiple allergens allergic rhinitis in children].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 32(21): 1646-1649, 2018 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-30400689
ABSTRACT
Objective:
Evaluation of the efficacy of standardized dust mite drops in sublingual immunotherapy(SLIT) for allergic rhinitis in children.Method:
A retrospective analysis of 174 children who received SLIT with standardized dermatophagoides farinae drops for 2 years.These patients had been divided into two groupsmonoasensitized group(n=61) and polysensitized group(n=113).The total medication score(TMS),total nasal symptoms score(TNSS) and inflammatory factors were evaluated before and after SLIT treatment.Result:
â After SLIT treatment for 2.0 year,the TNSS in the monosensitized group is(11.27±1.46) and(3.48±1.50),polyasensitized group is (11.54±1.50) and (3.59±1.56),there are significant difference of TNSS between two groups(P<0.01).But the improvements of the TNSS between the two groups have no significant difference(P>0.05),the monosensitized group is(7.68±3.23); polysensitized group is (8.14±2.56). â¡Two groups of children with TMS before and after treatment were obviously improved, monosensitized group is (1.67±0.43) and (0.52±0.40),polysensitized group is(1.64±0.44) and (0.55±0.41). There are significant difference of TMS between two groups(P<0.01).But the improvements of the TMS between the two groups have no obvious difference(P>0.05),the monsensitized group is(1.16±0.61); polysensitized group is(1.28±0.55).â¢Specific IgG4 serum is increased after treatment(P<0.01).â£After immunotherapy,the expression of IL4 and IL-17α is downîregulated, IL-2 and TGF-ß1 is up-regulated.Conclusion:
â Dust mites under the SLIT,can significantly improve the monosensitized and polyasensitized allergic children nasal symptoms,reduce the drug use, and two groups have the equivalent effect.â¡Dust mite drops SLIT,can be used to the monosensitized and polyasensitized allergic children.â¢The rise of dust mites specific IgG4 can be used as immunotherapy effective predictors.â£After immunotherapy, Thl/Th2 /Thl7 and Treg can be reîbalanced.
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Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China