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MAIT cells contribute to protection against lethal influenza infection in vivo.
van Wilgenburg, Bonnie; Loh, Liyen; Chen, Zhenjun; Pediongco, Troi J; Wang, Huimeng; Shi, Mai; Zhao, Zhe; Koutsakos, Marios; Nüssing, Simone; Sant, Sneha; Wang, Zhongfang; D'Souza, Criselle; Jia, Xiaoxiao; Almeida, Catarina F; Kostenko, Lyudmila; Eckle, Sidonia B G; Meehan, Bronwyn S; Kallies, Axel; Godfrey, Dale I; Reading, Patrick C; Corbett, Alexandra J; McCluskey, James; Klenerman, Paul; Kedzierska, Katherine; Hinks, Timothy S C.
Afiliação
  • van Wilgenburg B; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Loh L; Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, OX3 3SY, UK.
  • Chen Z; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Pediongco TJ; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Wang H; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Shi M; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Zhao Z; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Koutsakos M; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Nüssing S; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Sant S; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Wang Z; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • D'Souza C; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Jia X; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Almeida CF; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Kostenko L; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Eckle SBG; ARC Centre of Excellence in Advanced Molecular Imaging, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • Meehan BS; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Kallies A; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Godfrey DI; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Reading PC; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Corbett AJ; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • McCluskey J; ARC Centre of Excellence in Advanced Molecular Imaging, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • Klenerman P; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Kedzierska K; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
  • Hinks TSC; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia.
Nat Commun ; 9(1): 4706, 2018 11 09.
Article em En | MEDLINE | ID: mdl-30413689
Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lungs and can contribute to protection against pulmonary bacterial infection. MAIT cells are also activated during human viral infections, yet it remains unknown whether MAIT cells play a significant protective or even detrimental role during viral infections in vivo. Using murine experimental challenge with two strains of influenza A virus, we show that MAIT cells accumulate and are activated early in infection, with upregulation of CD25, CD69 and Granzyme B, peaking at 5 days post-infection. Activation is modulated via cytokines independently of MR1. MAIT cell-deficient MR1-/- mice show enhanced weight loss and mortality to severe (H1N1) influenza. This is ameliorated by prior adoptive transfer of pulmonary MAIT cells in both immunocompetent and immunodeficient RAG2-/-γC-/- mice. Thus, MAIT cells contribute to protection during respiratory viral infections, and constitute a potential target for therapeutic manipulation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Orthomyxoviridae / Influenza Humana / Células T Invariantes Associadas à Mucosa Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Orthomyxoviridae / Influenza Humana / Células T Invariantes Associadas à Mucosa Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália