Vitamin D deficiency and course of frailty in a depressed older population.
Aging Ment Health
; 24(1): 49-55, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-30430840
ABSTRACT
Objective:
To study the association between vitamin D levels and frailty, its components and course in a depressed sample.Methods:
Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates.Results:
Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95%-CI 0.45 - 0.90], p = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95%-CI 0.26 - 1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95%-CI 1.23 - 6.49], p=.015).Conclusions:
In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina D
/
Depressão
/
Fragilidade
Tipo de estudo:
Etiology_studies
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Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Aged80
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Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Aging Ment Health
Assunto da revista:
GERIATRIA
/
PSICOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Holanda