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Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function.
Tremblay-Laganière, Camille; Garneau, Léa; Mauger, Jean-François; Peshdary, Vian; Atlas, Ella; Nikolla, Alyssa Samantha; Chapados, Natalie Ann; Aguer, Céline.
Afiliação
  • Tremblay-Laganière C; Institut du Savoir Montfort - Recherche, 713 Montreal Rd, Ottawa, ON, K1K 0T2, Canada.
  • Garneau L; Faculty of Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
  • Mauger JF; Institut du Savoir Montfort - Recherche, 713 Montreal Rd, Ottawa, ON, K1K 0T2, Canada.
  • Peshdary V; Faculty of Medicine, Biochemistry, Microbiology and Immunology Department, University of Ottawa, Ottawa, ON, K1H 8L1, Canada.
  • Atlas E; Institut du Savoir Montfort - Recherche, 713 Montreal Rd, Ottawa, ON, K1K 0T2, Canada.
  • Nikolla AS; Faculty of Medicine, Biochemistry, Microbiology and Immunology Department, University of Ottawa, Ottawa, ON, K1H 8L1, Canada.
  • Chapados NA; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada.
  • Aguer C; Faculty of Medicine, Biochemistry, Microbiology and Immunology Department, University of Ottawa, Ottawa, ON, K1H 8L1, Canada.
Environ Sci Pollut Res Int ; 26(3): 2375-2386, 2019 Jan.
Article em En | MEDLINE | ID: mdl-30467749
ABSTRACT
In the past few years, polychlorinated biphenyls (PCBs), a class of environmental pollutants, have been associated with metabolism dysregulation. Muscle is one of the key regulators of metabolism because of its mass and its important role in terms of glucose consumption and glucose storage. It has been shown that muscle alterations, such as oxidative stress and mitochondrial dysfunction, contribute significantly to the development of metabolic diseases. No study has yet investigated the toxicological effect of PCBs on muscle mitochondrial function and oxidative stress in vivo. The aim of this study was to assess the effect of PCB126 in vivo exposure (single dose of 1.05 µmol/kg) on muscle mitochondrial function and oxidative stress in rats. PCB126-treated rats showed a marked increase in Cyp1a1 mRNA levels in skeletal muscles in association with a 40% reduction in state 3 oxygen consumption rate measured with complex I substrates in permeabilized muscle fibers. Furthermore, PCB126 exposure altered the expression of some enzymes involved in ROS detoxification such as catalase and glutaredoxin 2. Our results highlight for the first time a toxic effect of coplanar PCBs on skeletal muscle mitochondrial function and oxidative stress. This suggests that acute PCB exposure, by affecting muscle metabolism, could contribute to the development of metabolic disorders. Studies are needed to determine if lower-level but longer-term PCB exposure exhibits the same effect.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bifenilos Policlorados / Estresse Oxidativo / Músculo Esquelético / Mitocôndrias Musculares Limite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bifenilos Policlorados / Estresse Oxidativo / Músculo Esquelético / Mitocôndrias Musculares Limite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá