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Telomere length and redox balance in master endurance runners: The role of nitric oxide.
Sousa, Caio V; Aguiar, Samuel S; Santos, Patrick A; Barbosa, Lucas P; Knechtle, Beat; Nikolaidis, Pantelis T; Deus, Lysleine A; Sales, Marcelo M; Rosa, Erica C C C; Rosa, Thiago S; Lewis, John E; Andrade, Rosângela V; Simões, Herbert G.
Afiliação
  • Sousa CV; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil. Electronic address: cvsousa89@gmail.com.
  • Aguiar SS; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
  • Santos PA; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
  • Barbosa LP; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
  • Knechtle B; Institute of Primary Care, University of Zurich, Zurich, Switzerland.
  • Nikolaidis PT; Exercise Physiology Laboratory, Nikaia, Greece.
  • Deus LA; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
  • Sales MM; College of Physical Education, State University of Goiás, GO, Brazil.
  • Rosa ECCC; Graduate Program in Health Sciences, University of Brasília, DF, Brazil.
  • Rosa TS; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil.
  • Lewis JE; Department of Psychiatry & Behavioral Sciences, University of Miami, FL, USA.
  • Andrade RV; Graduate Program in Biotechnology, Catholic University of Brasília, DF, Brazil.
  • Simões HG; Graduate Program in Physical Education, Catholic University of Brasília, DF, Brazil. Electronic address: hgsimoes@gmail.com.
Exp Gerontol ; 117: 113-118, 2019 03.
Article em En | MEDLINE | ID: mdl-30481549
Leukocyte telomere length (LTL), a biological marker of aging that is associated with age-related diseases, is longer in master endurance runners (ER) than age-matched controls, but the underlying mechanisms are poorly investigated. The LTL, nitric oxide (NO), and redox balance of ER master runners were analyzed and compared to untrained middle-aged and young adults. We hypothesized that NO and redox balance at baseline would be related to longer LTL in ER athletes. Participants (n = 38) were long-term ER runners (n = 10; 51.6 ±â€¯5.2 yrs.; 28.4 ±â€¯9.4 yrs. of experience) and untrained age-matched (n = 17; 46.6 ±â€¯7.1 yrs) and young controls (n = 11; 21.8 ±â€¯4.0 yrs). Volunteers were assessed for anamnesis, anthropometrics, and blood sampling. Measurements of pro-and anti-oxidant status and DNA extraction were performed using commercial kits. Relative LTL was determined with qPCR analyses (T/S). While the middle-aged controls had shorter LTL than the young group, no difference was observed between ER athletes and young participants. A large effect size between the LTL of ER athletes and middle-aged controls (d = 0.85) was also observed. The ER athletes and untrained young group had better redox balance according to antioxidant/pro-oxidant ratios compared to middle-aged untrained participants, which also had lower values for redox parameters (TEAC/TBARS, SOD/TBARS, and CAT/TBARS; all p < 0.05). Furthermore, the NO level of ER athletes (175.2 ±â€¯31.9 µM) was higher (p < 0.05) than middle-aged controls (67.2 ±â€¯23.3 µM) and young participants (129.2 ±â€¯17.3 µM), with a significant correlation with LTL (r = 0.766; p = 0.02). In conclusion, ER runners have longer LTL than age-matched controls, which in turn may be related to better NO bioavailability and redox balance status.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corrida / Envelhecimento / Homeostase do Telômero / Óxido Nítrico Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Exp Gerontol Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corrida / Envelhecimento / Homeostase do Telômero / Óxido Nítrico Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Exp Gerontol Ano de publicação: 2019 Tipo de documento: Article