Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats.
Mol Med Rep
; 19(1): 452-460, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30483728
ABSTRACT
Cellulose in different forms has extensively been applied in biomedical treatments, including scaffolding, tissue engineering and tissue formation. To evaluate the therapeutic effects of a liquid bandage (LB) prepared with cellulose powders from Styela clava tunics (SCT) and Broussonetia kazinoki bark (BSLB) for healing cutaneous wounds, the remedial effects of a low concentration (LoBSLB) and a high concentration (HiBSLB) of BSLB on skin regeneration and toxicity in Sprague Dawley rats. Results indicated that the total area of skin involved in the surgical wound was lower in the BSLBtreated group compared with the Vehicletreated group at days 412, although some variations were observed in the HiBSLBtreated group. In addition, the BSLBtreated group showed significantly enhanced width of the reepithelialization region and epidermal thickness when compared with the Vehicletreated group. Furthermore, significant stimulation in the expression level of collagen1 and the signaling pathway of VEGF after topical application of BSLB was indicated. No liver or kidney toxicities were detected for either doses of BSLB. Overall, the results of the present study suggest that BSLB accelerates the process of wound healing in surgical skin wounds of Sprague Dawley rats through stimulation of reepithelialization and connective tissue formation, without any accompanying significant toxicity.
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Base de dados:
MEDLINE
Assunto principal:
Pós
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Pele
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Urocordados
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Cicatrização
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Celulose
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Broussonetia
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Ferida Cirúrgica
Limite:
Animals
Idioma:
En
Revista:
Mol Med Rep
Ano de publicação:
2019
Tipo de documento:
Article