Alternariol induced proliferation in primary mouse keratinocytes and inflammation in mouse skin is regulated via PGE<sub>2</sub>/EP2/cAMP/p-CREB signaling pathway.

Bansal, Megha; Singh, Neha; Alam, Shamshad; Pal, Saurabh; Satyanarayana, G N V; Singh, Dhirendra; Ansari, Kausar Mahmood

Alternariol induced proliferation in primary mouse keratinocytes and inflammation in mouse skin is regulated via PGE₂/EP2/cAMP/p-CREB signaling pathway.

Bansal, Megha; Singh, Neha; Alam, Shamshad; Pal, Saurabh; Satyanarayana, G N V; Singh, Dhirendra; Ansari, Kausar Mahmood.

Afiliação

Bansal M; Food Toxicology Laboratory, Food, Drug, and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Toxicology Research
Singh N; Food Toxicology Laboratory, Food, Drug, and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Toxicology Research
Alam S; Food Toxicology Laboratory, Food, Drug, and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India.
Pal S; Food Toxicology Laboratory, Food, Drug, and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Toxicology Research
Satyanarayana GNV; Analytical Chemistry Section, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India.
Singh D; Animal House Facility, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India.
Ansari KM; Food Toxicology Laboratory, Food, Drug, and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India. Electronic address: kmansari@iitr.res.in.

Toxicology ; 412: 79-88, 2019 01 15.

Article em En | MEDLINE | ID: mdl-30503586

Assuntos

Inflamação/induzido quimicamente; Queratinócitos/efeitos dos fármacos; Lactonas/toxicidade; Pele/efeitos dos fármacos; Animais; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; AMP Cíclico/metabolismo; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo; Ciclo-Oxigenase 2/metabolismo; Dinoprostona/metabolismo; Feminino; Inflamação/metabolismo; Inflamação/patologia; Queratinócitos/metabolismo; Camundongos; Receptores de Prostaglandina E Subtipo EP2/metabolismo; Transdução de Sinais/efeitos dos fármacos; Pele/metabolismo; Pele/patologia

Palavras-chave

Alternariol; Mycotoxins; PGE(2); Proliferation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Queratinócitos / Inflamação / Lactonas Limite: Animals Idioma: En Revista: Toxicology Ano de publicação: 2019 Tipo de documento: Article

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