The Structural Basis of Necroptotic Cell Death Signaling.
Trends Biochem Sci
; 44(1): 53-63, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30509860
ABSTRACT
The recent implication of the cell death pathway, necroptosis, in innate immunity and a range of human pathologies has led to intense interest in the underlying molecular mechanism. Unlike the better-understood apoptosis pathway, necroptosis is a caspase-independent pathway that leads to cell lysis and release of immunogens downstream of death receptor and Toll-like receptor (TLR) ligation. Here we review the role of recent structural studies of the core machinery of the pathway, the protein kinases receptor-interacting protein kinase (RIPK)1 and RIPK3, and the terminal effector, the pseudokinase mixed lineage kinase domain-like protein (MLKL), in shaping our mechanistic understanding of necroptotic signaling. Structural studies have played a key role in establishing models that describe MLKL's transition from a dormant monomer to a killer oligomer and revealing important interspecies differences.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
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Transdução de Sinais
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Morte Celular
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Proteína Serina-Treonina Quinases de Interação com Receptores
Limite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália