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Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes.
Smitheman, Kimberly N; Severson, Tesa M; Rajapurkar, Satyajit R; McCabe, Michael T; Karpinich, Natalie; Foley, James; Pappalardi, Melissa B; Hughes, Ashley; Halsey, Wendy; Thomas, Elizabeth; Traini, Christopher; Federowicz, Kelly E; Laraio, Jenny; Mobegi, Fredrick; Ferron-Brady, Geraldine; Prinjha, Rabinder K; Carpenter, Christopher L; Kruger, Ryan G; Wessels, Lodewyk; Mohammad, Helai P.
Afiliação
  • Smitheman KN; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Severson TM; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Rajapurkar SR; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • McCabe MT; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Karpinich N; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Foley J; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Pappalardi MB; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Hughes A; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA.
  • Halsey W; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA.
  • Thomas E; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA.
  • Traini C; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA.
  • Federowicz KE; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Laraio J; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Mobegi F; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Ferron-Brady G; Clinical Pharmacology and Modeling Sciences, GlaxoSmithKline, Collegeville, PA, USA.
  • Prinjha RK; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Carpenter CL; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Kruger RG; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Wessels L; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Mohammad HP; Faculty of EEMCS, Delft University of Technology, the Netherlands.
Haematologica ; 104(6): 1156-1167, 2019 06.
Article em En | MEDLINE | ID: mdl-30514804
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tretinoína / Leucemia Mieloide Aguda / Diferenciação Celular / Histona Desmetilases / Antineoplásicos Limite: Humans Idioma: En Revista: Haematologica Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tretinoína / Leucemia Mieloide Aguda / Diferenciação Celular / Histona Desmetilases / Antineoplásicos Limite: Humans Idioma: En Revista: Haematologica Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos