Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium.
Org Biomol Chem
; 17(1): 195-202, 2018 12 19.
Article
em En
| MEDLINE
| ID: mdl-30534799
ABSTRACT
Crotonols A and B (1 and 2), two tigliane diterpenoids featuring a rare C-7/C-14 cyclized and novel 5/7/7-fused carbon skeleton, along with the known tigliane wallichiioid A, were isolated from the leaves of Croton tiglium. Their structures were determined through spectroscopic methods, X-ray crystallography and ECD analysis. To the best of our knowledge, crotonol B (2) represents the first example of 13,14-seco-tigliane diterpenoids. Crotonols A and B displayed strong cytotoxic activities against the K562 cell line with IC50 values of 0.20 and 0.21 µM, respectively. Furthermore, crotonol A promoted the apoptosis of K562 cells through the cleavage of PARP and the accumulation of bax as well as the degradation of bcl-2.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apoptose
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Croton
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Diterpenos
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Butanóis
Limite:
Humans
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article