RAB38 promotes bladder cancer growth by promoting cell proliferation and motility.
World J Urol
; 37(9): 1889-1897, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-30535713
ABSTRACT
BACKGROUND:
Bladder cancer is the most common malignancy of urinary system with high morbidity and mortality. In general, the development and progression of bladder cancer are complicated pathological processes, and the treatment methods mainly include surgical resection, radiotherapy, chemotherapy, and combined therapy. In recent years, targeted therapy has made progress in the treatment of bladder cancer. Therefore, to improve survival rates of patients with advanced bladder cancer, novel therapeutic targets are still urgently needed. METHODS ANDRESULTS:
In this study, we found that RAB38 expressed in tumor tissues of patients with bladder cancer was linked to clinical features including pTNM stage and tumor recurrence, and positively correlated with the poor prognosis of bladder cancer. Notably, further results indicated that depletion of RAB38 could significantly inhibit the proliferation and motility of two types of human bladder cancer cells, T24 and 5637 cells. In addition, RAB38 ablation obviously blocked tumor growth and development in mice compared with control.CONCLUSION:
In conclusion, this study provides significant evidence that RAB38 promotes the development of bladder cancer and provides a novel therapeutic target of bladder cancer.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
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Movimento Celular
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Proteínas rab de Ligação ao GTP
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Proliferação de Células
Limite:
Animals
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Humans
Idioma:
En
Revista:
World J Urol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China