Generation of a Primary Hyperoxaluria Type 1 Disease Model Via CRISPR/Cas9 System in Rats.

Zheng, Rui; Fang, Xiaoliang; He, Lei; Shao, Yanjiao; Guo, Nana; Wang, Liren; Liu, Mingyao; Li, Dali; Geng, Hongquan

Zheng, Rui; Fang, Xiaoliang; He, Lei; Shao, Yanjiao; Guo, Nana; Wang, Liren; Liu, Mingyao; Li, Dali; Geng, Hongquan.

Afiliação

Zheng R; Department of Pediatric Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fang X; Department of Pediatric Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
He L; Department of Pediatric Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shao Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Guo N; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Wang L; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Liu M; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Li D; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Geng H; Department of Pediatric Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Curr Mol Med ; 18(7): 436-447, 2018.

Article em En | MEDLINE | ID: mdl-30539697

Assuntos

Sistemas CRISPR-Cas; Modelos Animais de Doenças; Hiperoxalúria Primária; Nefrocalcinose; Transaminases/deficiência; Animais; Glioxilatos/metabolismo; Hiperoxalúria Primária/genética; Hiperoxalúria Primária/patologia; Hiperoxalúria Primária/urina; Mitocôndrias/genética; Mitocôndrias/metabolismo; Nefrocalcinose/genética; Nefrocalcinose/patologia; Nefrocalcinose/urina; Oxalatos/urina; Ratos; Ratos Transgênicos

Palavras-chave

CRISPR/Cas9; Primary hyperoxaluria type 1; gene editing; kidney; mitochondria; nephrocalcinosis.

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperoxalúria Primária / Modelos Animais de Doenças / Sistemas CRISPR-Cas / Transaminases / Nefrocalcinose Limite: Animals Idioma: En Revista: Curr Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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