Dendritic sodium spikes endow neurons with inverse firing rate response to correlated synaptic activity.
J Comput Neurosci
; 45(3): 223-234, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30547292
ABSTRACT
Many neurons possess dendrites enriched with sodium channels and are capable of generating action potentials. However, the role of dendritic sodium spikes remain unclear. Here, we study computational models of neurons to investigate the functional effects of dendritic spikes. In agreement with previous studies, we found that point neurons or neurons with passive dendrites increase their somatic firing rate in response to the correlation of synaptic bombardment for a wide range of input conditions, i.e. input firing rates, synaptic conductances, or refractory periods. However, neurons with active dendrites show the opposite behavior for a wide range of conditions the firing rate decreases as a function of correlation. We found this property in three types of models of dendritic excitability a Hodgkin-Huxley model of dendritic spikes, a model with integrate and fire dendrites, and a discrete-state dendritic model. We conclude that fast dendritic spikes confer much broader computational properties to neurons, sometimes opposite to that of point neurons.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Potenciais de Ação
/
Canais de Sódio
/
Modelos Neurológicos
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
J Comput Neurosci
Assunto da revista:
INFORMATICA MEDICA
/
NEUROLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França