Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
Invest New Drugs
; 37(4): 693-701, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-30547316
ABSTRACT
Purpose To determine the maximum tolerated dose (MTD) of F14512, a topoisomerase II inhibitor designed to target cancer cells through the polyamine transport system, (three-hour daily infusion given for 3 consecutive days every 3 weeks) in platinum-refractory or resistant ovarian cancer. Other objectives were safety, pharmacokinetics (PK), PK/pharmacodynamics relationship, and efficacy. Methods This was an open-label, dose-escalation, multicenter phase I study. Results Eleven patients were enrolled and were treated at dose levels (DLs) of 10 and 5 mg/m2/day. All patients received the 3 injections per cycle as per study protocol (median, 1 cycle (Ferlay et al. Int J Cancer 136E359-386, 2015; Siegel et al. CA Cancer J Clin 655-29, 2015; Oronsky et al. Med Oncol 34103, 2017; Barret et al. Cancer Res 689845-9853, 2008; Ballot et al. Apoptosis 17364-376, 2012; Brel et al. Biochem Pharmacol 821843-1852, 2011; Gentry et al. Biochemistry 503240-3249, 2011; Kruczynski et al. Investig New Drugs 299-21, 2011; Chelouah et al. PLoS One 6e23597, 2011)) with no dose reductions. At DL 10 mg/m2/day, 6 dose-limiting toxicities (DLTs) were reported (3/4 evaluable patients 2 grade 3 febrile neutropenia, 1 grade 4 neutropenia lasting at least 7 days, 1 grade 3 nausea, 1 decreased appetite, and 1 grade 3 asthenia). At dose 5 mg/m2/day, 2 DLTs were reported (2/6 treated patients 2 grade 3 febrile neutropenia). Both DLs were defined as MTD. Stable disease was reported as best overall response in 2 (40%) patients having both received 9 cycles, one at each DL. 90.9% of patients experienced grade 4 neutropenia, but for only one (9.1%) it was reported as a serious adverse event. Conclusion Although there was some encouraging efficacy signal, grade 4 neutropenia led to complications and it was decided to stop the study. A DL below 5 mg/m2/day was not tested as this would not allow reaching the minimum serum concentration needed for the pharmacological activity of the drug.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
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Podofilotoxina
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Inibidores da Topoisomerase II
Tipo de estudo:
Clinical_trials
Limite:
Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Invest New Drugs
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
França