[Frequency of adrenal hemorrhage in fatal forms of purpura fulminans in children. Etiopathogenic and therapeutic considerations]. / Fréquence des hémorragies surrénaliennes au cours des formes fatales de purpura fulminans de l'enfant. Considérations étio-pathogéniques et thérapeutiques.
Pediatrie
; 43(6): 545-50, 1988.
Article
em Fr
| MEDLINE
| ID: mdl-3054802
ABSTRACT
Between 1971 and 1985, 43 children died of purpura fulminans in our intensive care unit 11 had autopsy and adrenal haemorrhage was observed in 8 (73%). All these patients had an extensive purpura and a severe disseminated intravascular coagulation. Our series confirms the findings of previous studies 69 autopsies showed 51 cases (74%) of macroscopic adrenal haemorrhage. Adrenal haemorrhage may be only one manifestation of multiple system organ failure consecutive to septic shock; however, its association with low plasma cortisol levels (as previously reported) suggests that glucocorticoid replacement therapy should be reconsidered in purpura fulminans.
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Base de dados:
MEDLINE
Assunto principal:
Púrpura
/
Choque Séptico
/
Doenças das Glândulas Suprarrenais
/
Hemorragia
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Humans
/
Infant
Idioma:
Fr
Revista:
Pediatrie
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
França