Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.
J Cell Biochem
; 120(3): 4613-4619, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30552709
ABSTRACT
BACKGROUND:
Recently, the role of α-adducin rs4961 polymorphism in hypertension (HTN) was intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between α-adducin rs4961 polymorphism and the likelihood of HTN.METHODS:
Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios with 95% confidence intervals were used to assess the relationship between α-adducin rs4961 polymorphism and HTN.RESULTS:
A total of 33 studies with 40 432 participants were analyzed. Significant associations with the likelihood of HTN were detected for the α-adducin rs4961 polymorphism with fixed effect models (FEM) (dominant model P = 0.003; allele model P = 0.003), but not with random effect models (REM). Further subgroup analysis according to ethnicity of participants revealed that the α-adducin rs4961 polymorphism was significantly associated with the likelihood of HTN in Asians (7721 cases and 8299 controls) with both FEMs (dominant model P < 0.0001; additive model P = 0.01; allele model P < 0.0001) and REMs (dominant model P = 0.0005; additive model P = 0.03; allele model P = 0.0006).CONCLUSIONS:
Our findings indicate that the α-adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Proteínas de Ligação a Calmodulina
/
Povo Asiático
/
Hipertensão
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Female
/
Humans
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Male
Idioma:
En
Revista:
J Cell Biochem
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China