Novel truncating variants expand the phenotypic spectrum of KAT6B-related disorders.
Am J Med Genet A
; 179(2): 290-294, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30569622
ABSTRACT
Say-Barber-Biesecker-Young-Simpson syndrome (SBBYSS) and Genitopatellar syndrome (GTPTS) are very rare conditions caused by KAT6B truncating variants. Because of both syndromes often share common features the associated phenotypes are usually grouped under the term "KAT6B-related disorders." However, particular signs of each syndrome have been reported and their appearance seems to be dependent on where the KAT6B variant is located. Thus, whereas truncating variants associated with SBBYSS have their highest density in the distal part of exon 18, those resulting in GTPTS are distributed between the end of exon 17 and beginning of exon 18. Here, we reported two de novo heterozygous KAT6B truncating variants. The first variant (c.5802delA; p.A1935Pfs*16), identified in a boy with SSBYSS phenotype, resulting in the most distal KAT6B truncating variant reported up-to-date in the scientific literature. The second variant (c.3152delG; p.S1051Tfs*63), located in a region hitherto defined as specific of SBBYSS, seems to cause an overlapping SBBYSS/GTPTS phenotype. The clinical and genetic characterization of these patients could contribute to the understanding of the KAT6B-related disorders.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Patela
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Transtornos Psicomotores
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Escroto
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Anormalidades Urogenitais
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Anormalidades Múltiplas
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Blefarofimose
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Anormalidades Craniofaciais
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Hipotireoidismo Congênito
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Histona Acetiltransferases
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Cardiopatias Congênitas
Tipo de estudo:
Prognostic_studies
Limite:
Child
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Humans
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Male
Idioma:
En
Revista:
Am J Med Genet A
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Espanha