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New ingol-type diterpenes from the latex of Euphorbia resinifera.
Wang, Shu-Yun; Li, Guo-Yu; Zhang, Ke; Wang, Hang-Yu; Liang, Hong-Gang; Huang, Chao; Huang, Jian; Wang, Jin-Hui; Yang, Bao-Feng.
Afiliação
  • Wang SY; School of Pharmacy, Henan University , Kaifeng 475004 , China.
  • Li GY; Department of Medicinal Chemistry and Natural Medicine Chemistry (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University , Harbin 832001 , China.
  • Zhang K; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 150081 , China.
  • Wang HY; School of Pharmacy, Shihezi University (Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education) , Shihezi 110016 , China.
  • Liang HG; School of Pharmacy, Shihezi University (Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education) , Shihezi 110016 , China.
  • Huang C; School of Pharmacy, Shihezi University (Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education) , Shihezi 110016 , China.
  • Huang J; Department of Medicinal Chemistry and Natural Medicine Chemistry (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University , Harbin 832001 , China.
  • Wang JH; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 150081 , China.
  • Yang BF; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 150081 , China.
J Asian Nat Prod Res ; 21(11): 1075-1082, 2019 Nov.
Article em En | MEDLINE | ID: mdl-30607997
ABSTRACT
Two new ingol-type diterpenes, euphoresins A-B (1-2), have been isolated from the methanol extract of Euphorbium, the latex of Euphorbia resinifera Berg. Their structures were established on the basis of extensive analyses of their HR-ESI-MS, IR, UV, 1D, and 2D NMR spectra. The absolute configurations were confirmed by Mosher's method and circular dichroism (CD) analyses. The two compounds were tested for their cytotoxic activities against MCF-7, U937, and C6 cancer cell lines, but they both exhibited little cytotoxic effect.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Euphorbia / Diterpenos / Antineoplásicos Fitogênicos Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Euphorbia / Diterpenos / Antineoplásicos Fitogênicos Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China