GII.4 Norovirus Protease Shows pH-Sensitive Proteolysis with a Unique Arg-His Pairing in the Catalytic Site.

Viskovska, Mariya A; Zhao, Boyang; Shanker, Sreejesh; Choi, Jae-Mun; Deng, Lisheng; Song, Yongchen; Palzkill, Timothy; Hu, Liya; Estes, Mary K; Venkataram Prasad, B V

Viskovska, Mariya A; Zhao, Boyang; Shanker, Sreejesh; Choi, Jae-Mun; Deng, Lisheng; Song, Yongchen; Palzkill, Timothy; Hu, Liya; Estes, Mary K; Venkataram Prasad, B V.

Afiliação

Viskovska MA; The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Zhao B; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Shanker S; The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Choi JM; The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Deng L; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Song Y; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Palzkill T; The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Hu L; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Estes MK; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Venkataram Prasad BV; The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.

J Virol ; 93(6)2019 03 15.

Article em En | MEDLINE | ID: mdl-30626675

Assuntos

Arginina/metabolismo; Domínio Catalítico/genética; Histidina/metabolismo; Norovirus/metabolismo; Peptídeo Hidrolases/metabolismo; Sequência de Aminoácidos; Infecções por Caliciviridae/metabolismo; Domínio Catalítico/fisiologia; Variação Genética/genética; Genótipo; Humanos; Concentração de Íons de Hidrogênio; Norovirus/genética; Filogenia; Proteólise

Palavras-chave

Arg-His pairing; GII.4 protease; X-ray crystallography; antiviral agents; norovirus; protease inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Arginina / Domínio Catalítico / Norovirus / Histidina Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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