Serum Calprotectin in Adolescents With Inflammatory Bowel Disease-A Pilot Investigation.
J Pediatr Gastroenterol Nutr
; 68(5): 669-675, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30628981
ABSTRACT
OBJECTIVES:
Fecal calprotectin (FC) is a well-integrated parameter in the monitoring of adolescent patients with inflammatory bowel disease (IBD). However, measurement of FC is limited by day-to-day-variation and by the feces consistency. Furthermore, adolescents are often noncompliant to deliver fecal sampling leading to suboptimal monitoring. Consequently, we see the need of a substitute biomarker whenever measurement of FC fails and aimed to investigate serum calprotectin (SC) in adolescents with IBD.METHODS:
In cross sectional data from 19 ulcerative colitis (UC) patients <18 years old, a Spearman correlation was used to analyze the correlation between SC, FC, C-reactive protein (CRP) and endoscopic and symptom scores. In longitudinal data collected from 20 UC and Crohn disease (CD) patients (10-17 years old), Mixed Effect Models (MEM) were used to analyze the association between SC, FC, CRP, and symptom scores.RESULTS:
We found positive correlations between SC (19 samples) and the endoscopic score, symptom score, and CRP (râ=â0.56, Pâ=â0.01; râ=â0.64, Pâ=â0.003; râ=â0.97, Pâ<â0.0001). We found no significant correlation between SC and FC. In 27 samples from UC patients, the association of SC with FC and CRP were positive and significant (Pâ=â0.004, estimateâ=â0.32; Pâ=â0.0001, estimateâ=â0.002). The association between SC and symptom score was insignificant. In 49 samples from CD patients, the association between SC and CRP was significant (Pâ=â0.02, estimateâ=â0.002) whereas associations between SC and FC and symptom score were insignificant.CONCLUSIONS:
In the current pilot study, we found a correlation between SC and the endoscopically assessed inflammation in UC. SC may have the potential to improve disease monitoring of adolescent patients.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
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Colite Ulcerativa
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Doença de Crohn
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Complexo Antígeno L1 Leucocitário
Tipo de estudo:
Evaluation_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Ano de publicação:
2019
Tipo de documento:
Article