Dual-Modal In Vivo Fluorescence/Photoacoustic Microscopy Imaging of Inflammation Induced by GFP-Expressing Bacteria.
Sensors (Basel)
; 19(2)2019 Jan 10.
Article
em En
| MEDLINE
| ID: mdl-30634579
ABSTRACT
In this study, dual-modal fluorescence and photoacoustic microscopy was performed for noninvasive and functional in vivo imaging of inflammation induced by green fluorescent protein (GFP) transfected bacteria in mice ear. Our imaging results demonstrated that the multimodal imaging technique is able to monitor the tissue immunovascular responses to infections with molecular specificity. Our study also indicated that the combination of photoacoustic and fluorescence microscopy imaging can simultaneously track the biochemical changes including the bacterial distribution and morphological change of blood vessels in the biological tissues with high resolution and enhanced sensitivity. Consequently, the developed method paves a new avenue for improving the understanding of the pathology mechanism of inflammation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Orelha
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Técnicas Fotoacústicas
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Inflamação
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Microscopia de Fluorescência
Limite:
Animals
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Humans
Idioma:
En
Revista:
Sensors (Basel)
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China