Reductant-Free Aerobic Hydroxylation of Isoquinoline-1,3(2 H,4 H)-dione Derivatives.
J Org Chem
; 84(4): 2316-2324, 2019 02 15.
Article
em En
| MEDLINE
| ID: mdl-30642180
ABSTRACT
Base-catalyzed efficient hydroxylation of isoquinoline-1,3(2 H,4 H)-diones with air under transition-metal-free and reductant-free conditions was established. This methodology is essentially mild and compatible with a broad range of substrates, including aryl, heteroaryl, and alkyl groups. Also, the product could be simply transformed into a hydroxylated tetrahydroisoquinoline core structure through a reductive process.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China