Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease-a case report and literature review.
Acta Neurochir (Wien)
; 161(2): 343-349, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30652202
ABSTRACT
BACKGROUND:
Hemangioblastomas (HB) are benign tumors of the central nervous system (CNS) that can appear sporadic or as part of von Hippel-Lindau (VHL) disease. It is often curable with surgical resection, but upon relapse, the disease exhibits a treatment-refractory course. CASE REPORT A patient treated for sporadic cerebellar HB relapsed 12 years post-surgery. She developed disseminated disease throughout the CNS, including leptomeningeal manifestations. Repeat surgery and craniospinal radiation therapy were unsuccessful.CONCLUSION:
This case is in line with previous publications on disseminated non-VHL HB. Available treatment options are inefficient, emphasizing the need for improved understanding of HB biology to identify therapeutic targets.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cerebelares
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Hemangioblastoma
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Doença de von Hippel-Lindau
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
/
Systematic_reviews
Limite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Acta Neurochir (Wien)
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Noruega