Cyanosomes: A pilot study.

ABSTRACT

Cyanobacteria are the most primitive, oxygen-evolving prokaryotic organism. Several, conspicuous investigations have been done around lipids from cyanobacteria. However, to date and to the best of our knowledge, no study was conducted to formulate and evaluate liposomal vesicles prepared from cyanobacterial lipid. In the present study, cyanosomes were formulated using natural lipids extracted from the cyanobacterium Synechococcus elongatus PCC7942 which were further loaded with thymoquinone. The results showed that the prepared cyanosomes were homogenous with an overall negative charge of particle size ranging between 200 to 210 nm and entrapment efficacy was 70.9 ± 1.86%. The obtained release profiles demonstrated sustained drug release pattern. The study of encapsulated thymoquinone on CCl4 induced liver insult in balb/c mice revealed the better efficacy of encapsulated thymoquinone as compared to thymoquinone alone indicating cyanosome as a promising candidate for drug carrier. However, more studies are required to establish the safety profile, pharmacokinetic pattern and biodistribution parameters of cyanosome for its clinical intricacies in future applications.