Reduction of T Cells and Hsa-miR150-5p in Female Canoeing Athletes: Preliminary Evidence Between Exercise Training and Immune.
J Strength Cond Res
; 36(11): e106-e113, 2022 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-30664110
ABSTRACT
ABSTRACT Xiao, F, Yang, Y, Xiao, L, Xia, Z, Wang, L, Yang, K, and Wang, S. Reduction of T cells and hsa-miR150-5p in female canoeing athletes Preliminary evidence between exercise training and immune. J Strength Cond Res 36(11) e106-e113, 2022-This article aims to reveal the alteration of immune profile in teenage canoeing athletes, by which applies a clue for regulation of exercise on human immune. Thirty-one teenagers of female canoeing athletes and age-matched subjects participated in this research. Peripheral leukocytes' microRNAs (miRNAs) were analyzed using Agilent human microRNA 2.0 and gene software. The miRNA candidates were quantified by reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). The percentages of various lymphocytes were tested using flow cytometry. There were 6 miRNAs (hsa-miR150-5p, 31-5p, 3659, 4419a, 650, and 8485) lower in canoeing athletes, and the reduction of miR-150 was identified by RT-qPCR ( p = 0.021). Canoeing athletes had lower percent of CD3 + T cells than the subjects with no exercise training had ( p < 0.001), but the ratio of CD4 + to CD8 + and the percent of CD4 + T cells and CD8 + T cells showed no significant difference between these 2 groups. T cells and hsa-miR150-5p are sensitive to the long-time heavy exercise training, and the exercise for winning competition regulates the immune system by inhibiting T cells and hsa-miR150-5p.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
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Esportes Aquáticos
Limite:
Adolescent
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Female
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Humans
Idioma:
En
Revista:
J Strength Cond Res
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China