Testing the Neuroprotective Properties of PCSO-524® Using a Neuronal Cell Cycle Suppression Assay.
Mar Drugs
; 17(2)2019 Jan 24.
Article
em En
| MEDLINE
| ID: mdl-30682813
ABSTRACT
Cell cycle reentry is a unified mechanism shared by several neurodegenerative diseases, including Alzheimer's disease (AD) and Ataxia Telangiectasia (A-T). This phenotype is often related to neuroinflammation in the central nervous system. To mimic brain inflammation in vitro, we adopted the previously established method of using conditioned medium collected from activated THP-1 cells and applied it to both differentiated HT22 cells and primary neurons. Unscheduled cell cycle events were observed in both systems, indicating the potential of this approach as an in vitro model of neurodegenerative disease. We used this assay to measure the neuroprotective effects of New Zealand green-lipped mussel extract, PCSO-524®, to protect post-mitotic cells from cell cycle reentry. We found that, both in vitro and in an animal model, PCSO-524® displayed promising neuroprotective effects, and thus has potential to postpone or prevent the onset of neurodegenerative disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
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Bivalves
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Fármacos Neuroprotetores
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Neurônios
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mar Drugs
Assunto da revista:
BIOLOGIA
/
FARMACOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China