Interactive effects of adiposity and insulin resistance on the impaired lung function in asthmatic adults: cross-sectional analysis of NHANES data.
Ann Hum Biol
; 46(1): 56-62, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30712386
ABSTRACT
BACKGROUND:
Obesity is considered a risk factor for both asthma and insulin resistance in adults. Insulin resistance (IR) also influences pulmonary function in the non-obese population.AIM:
To investigate the modifying effect of insulin resistance on the predictive role of anthropometric measures in the estimation of impaired lung function among asthmatic adults. SUBJECTS ANDMETHODS:
A cross-sectional study of 1276 adults extracted from the NHANES 2009-2012 database was performed. Adjusted multiple linear regression was conducted to analyse the contributory role of obesity and IR in predicting lung function among asthmatic adults.RESULTS:
BMI, waist circumference (WC) and waist-to-height ratio (WHtR) showed significantly negative correlations with FVC (r=-0.24, -0.18, -0.39, respectively; p < 0.001), FEV1(r=-0.24, -0.21, -0.40, respectively; p < 0.001) and FEF 25-75% (r=-0.15, -0.18, -0.27, respectively; p < 0.001). Even after adjustment for the covariates (age, gender, smoking history and standing height), BMI and HOMA-IR had significant relationships with FVC (ß= -10.3; p < 0.01 and ß= -16.0; p < 0.05) and FEV1 (ß= -8.7; p < 0.01 and ß= -11.7; p < 0.05). BMI could significantly predict the decreased FVC (ß= -13.7; p < 0.01) and FEV1 (ß= -10.7; p < 0.01) only in the insulin resistant asthmatics.CONCLUSION:
WHtR and IR predict impaired lung function in overweight/obese asthmatic adults independently. IR also modifies the association between excessive adiposity and respiratory function in asthmatic adults.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Testes de Função Respiratória
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Asma
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Resistência à Insulina
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Adiposidade
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Pulmão
/
Obesidade
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Ann Hum Biol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Reino Unido