Total synthesis of (±)-galanthamine from GABA through regioselective aryne insertion.
Org Biomol Chem
; 17(8): 2192-2198, 2019 02 20.
Article
em En
| MEDLINE
| ID: mdl-30720819
ABSTRACT
The total synthesis of (±)-galanthamine is achieved in â¼5% overall yield using a key regioselective aryne insertion reaction into a GABA (γ-amino butyric acid) derivative. The strategy presented involves only two sub-critical temperature reactions and less than five chromatographic purifications to achieve the synthesis of galanthamine.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Índia